Rice: Unconventional Wisdom
Seminar
Physics & Astronomy
Speaker: John Collier
Harvard University

  Biophysics - TOWARDS UNDERSTANDING OF BACTERIAL TOXIN TRANSLOCATION
Friday, November 13, 2009
1:00 PM  to 2:00 PM
116  Herzstein Hall (Physics Lab)
Rice University
6100 Main St
Houston, Texas, USA

NAS Election Citation: Collier's contributions include demonstrating that diphtheria toxin blocks protein synthesis by inactivating Elongation Factor-2; elucidating diphtheria toxin structure, as containing enzymatic (A) and binding (B) fragments; identifying Glu-l48 as a key active-site residue; developing A-chain immunotoxin concepts; crystallizing diphtheria and Pseudomonas toxins and determining Pseudomonas toxin's structure at 3 Angstrom.


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